Description

1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Ethyl Ester, (1S)- is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of complex bioactive molecules. Pharmaceutical research and development laboratories primarily need it for the synthesis of novel drug candidates, particularly in neurological and cardiovascular therapeutic areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential active pharmaceutical ingredients (APIs), especially for alkaloid-derived therapeutics.
• Neurological Research: Used in the development of compounds targeting neurotransmitter pathways, potentially for conditions like Parkinson's disease or depression.
• Cardiovascular Drug Discovery: Serves as a precursor for molecules being investigated for hypertension and other cardiovascular disorders.
• Asymmetric Synthesis: Utilized in academic and industrial research to construct complex molecular architectures with high enantiomeric purity.
• Chemical Biology Probes: Acts as a scaffold for developing tool compounds to study enzyme function and receptor interactions.
• Process Chemistry Development: Employed in route scouting and optimization for scalable manufacturing of chiral drugs.

Basic Information

Product Name	1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Ethyl Ester, (1S)-
CAS No.	17447-45-9
Molecular Formula	C₁₅H₂₁NO₄
Molecular Weight	279.33 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolineacetic acid ethyl ester; (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1-isoquinolineacetic acid ethyl ester; Ethyl (1S)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolineacetate; (S)-Tetrahydropapaverine ethyl ester derivative; (S)-THP-Et ester; (S)-6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic acid ethyl ester; (1S)-1,2,3,4-Tetrahydro-6,7-dimethoxyisoquinoline-1-acetic acid ethyl ester
EINECS	Contact for details

Quality Control

Our 1-Isoquinolineacetic Acid, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-, Ethyl Ester, (1S)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.