Description

T-Butyldimethylisopropoxylsilane is a specialized organosilicon compound, specifically a silyl ether, known for its role as a versatile protecting group and reagent in advanced organic synthesis. Its value lies in its ability to selectively protect hydroxyl groups under mild conditions, offering superior stability against a range of subsequent chemical transformations compared to simpler silyl ethers. This makes it an essential intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate Synthesis: Key protecting group reagent for hydroxyl functionalities in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the synthesis of advanced pesticides and herbicides where selective protection is required during the building of the active compound.
• Fine Chemical & Specialty Material Manufacturing: Employed in the production of liquid crystals, advanced polymers, and other high-value specialty chemicals.
• Academic & Industrial R&D: A critical tool in research laboratories for method development and the synthesis of novel organic compounds.
• Peptide & Carbohydrate Chemistry: Useful for the temporary protection of sensitive hydroxyl groups during the synthesis of complex biomolecules.

Basic Information

Product Name	T-Butyldimethylisopropoxylsilane
CAS No.	17348-66-2
Molecular Formula	C9H22O2Si
Molecular Weight	190.36 g/mol
Synonyms	tert-Butyldimethyl(isopropoxy)silane; (Isopropoxy)(tert-butyl)dimethylsilane; t-Butyldimethylisopropoxysilane; TBDMIPS; TBDIPS-OiPr; (Isopropoxy)dimethyl-tert-butylsilane; tert-Butyldimethylisopropoxysilane; 1,1-Dimethylethyl-dimethyl(isopropoxy)silane
EINECS	Contact for details

Quality Control

Our production of T-Butyldimethylisopropoxylsilane adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including Gas Chromatography (GC) and NMR to verify identity and assay. A comprehensive Certificate of Analysis (COA) detailing purity, physical properties, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.