Description

(1,2,3,4-Tetrahydroisoquinolin-1-Yl)Methanol Hydrochloride is a high-purity organic salt of significant interest in advanced chemical synthesis. This compound serves as a versatile and critical chiral building block for the development of complex pharmaceutical molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and production of active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially for central nervous system (CNS) and cardiovascular therapeutics.
• Alkaloid Synthesis: Used as a foundational scaffold for constructing tetrahydroisoquinoline-based natural products and their analogs in medicinal chemistry research.
• Asymmetric Catalysis Research: Employed as a precursor or ligand in the development of novel chiral catalysts for stereoselective reactions.
• Chemical Biology Probes: Serves as a core structure for designing and synthesizing molecular probes to study enzyme function and receptor interactions.
• Process Chemistry Development: Used in route scouting and optimization for the scalable, GMP-compliant manufacturing of target APIs.

Basic Information

Item	Detail
Product Name	(1,2,3,4-Tetrahydroisoquinolin-1-Yl)Methanol Hydrochloride
CAS No.	17163-39-2
Molecular Formula	C10H14ClNO
Molecular Weight	199.68 g/mol
Synonyms	1-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1,2,3,4-Tetrahydro-1-isoquinolinyl)methanol hydrochloride; 1,2,3,4-Tetrahydro-1-isoquinolinemethanol hydrochloride; THIQ-Methanol HCl; 1-Hydroxymethyl-1,2,3,4-tetrahydroisoquinoline HCl; 1-(Hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline HCl; 1,2,3,4-Tetrahydroisoquinoline-1-methanol hydrochloride
EINECS	Contact for details

Quality Control

Our (1,2,3,4-Tetrahydroisoquinolin-1-Yl)Methanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A detailed Certificate of Analysis (COA) documenting identity, purity (HPLC), chiral purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.