Description

(S)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a fluorinated indole side chain, which is critical for modulating biological activity and metabolic stability. This compound serves as a sophisticated building block for the research and development of novel pharmaceuticals, particularly in the fields of oncology and neurology. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical R&D, biotechnology, and advanced fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of targeted therapeutic agents, including kinase inhibitors and receptor modulators.
• Peptidomimetics Research: Used to incorporate fluorinated tryptophan analogs into peptide chains to enhance binding affinity, selectivity, and in vivo stability.
• Chemical Biology Probes: Serves as a precursor for fluorescent or affinity tags to study protein-protein interactions and enzyme mechanisms.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	(S)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid
CAS No.	16626-02-1
Molecular Formula	C11H11FN2O2
Molecular Weight	222.22 g/mol
Synonyms	5-Fluoro-DL-tryptophan; (S)-5-Fluorotryptophan; 5-Fluoro-L-tryptophan; 5-F-Trp; F5W; 5-Fluoro-1H-indole-3-alanine; (S)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid; L-5-Fluorotryptophan
EINECS	Contact for details

Quality Control

Our production of (S)-2-Amino-3-(5-Fluoro-1H-Indol-3-Yl)-Propionic Acid adheres to stringent quality protocols suitable for research and pharmaceutical applications. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and MS to ensure identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support regulatory documentation needs for pre-clinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.