Description

4-Iodo-2-Methylthiophene is a halogenated heterocyclic building block of significant importance in advanced organic synthesis. This compound serves as a versatile intermediate for constructing complex molecular architectures, particularly in the development of pharmaceuticals and functional materials. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as cross-coupling reactions and the synthesis of novel thiophene derivatives.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing functionalized thiophene cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the thiophene scaffold.
• Material Science: Serves as a precursor for conductive polymers, organic semiconductors, and other electronic materials due to the thiophene moiety.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings to form carbon-carbon bonds.
• Ligand and Catalyst Development: Used to create novel ligands for metal complexes and catalysts in asymmetric synthesis.
• Chemical Research: A valuable reagent for academic and industrial research in exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	4-Iodo-2-Methylthiophene
CAS No.	16494-35-2
Molecular Formula	C5H5IS
Molecular Weight	224.06 g/mol
Synonyms	2-Methyl-4-iodothiophene; 4-Iodo-2-methylthiophene; 2-Methyl-4-iodothiophene; 4-Iodo-2-methylthiophene; Thiophene, 4-iodo-2-methyl-; 2-Methylthiophene, 4-iodo-; Iodomethylthiophene
EINECS	Contact for details

Quality Control

Our 4-Iodo-2-Methylthiophene is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to verify identity and purity. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.