Description

6B-Hydroxy Cortisol is a significant metabolite of cortisol, the primary human stress hormone, offering a critical window into adrenal function and steroid metabolism. This compound is essential for researchers and developers in the life sciences, providing a high-purity reference standard for analytical and diagnostic applications. It is primarily utilized in pharmaceutical R&D, clinical diagnostics for endocrine disorder assessment, and as a key biochemical tool in metabolic studies.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification of cortisol metabolites in drug metabolism and pharmacokinetic (DMPK) studies.
• Clinical Diagnostics: Used in the development and calibration of immunoassays and LC-MS/MS methods to accurately measure adrenal cortex activity and diagnose related disorders.
• Biochemical Research: A vital tool for investigating the 6β-hydroxylation pathway of cortisol, a major route of steroid metabolism mediated by cytochrome P450 enzymes.
• Endocrinology Studies: Facilitates research into cortisol metabolism variations under different physiological and pathological conditions.
• Quality Control: Employed by manufacturers of in-vitro diagnostic (IVD) kits to ensure the accuracy and reliability of their cortisol metabolite testing products.

Basic Information

Product Name	6B-Hydroxy Cortisol
CAS No.	16355-29-6
Molecular Formula	C21H30O6
Molecular Weight	378.46 g/mol
Synonyms	6β-Hydroxycortisol; 6β-Hydroxyhydrocortisone; 11β,17α,21-Trihydroxy-6β-pregn-4-ene-3,20-dione; (6β,11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione; Cortisol 6β-ol; 6β-OH-Cortisol; NSC 113935
EINECS	Contact for details

Quality Control

Our 6B-Hydroxy Cortisol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and diagnostic applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is light-sensitive and easily oxidized; for long-term storage, consider under an inert atmosphere. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.