Description

(R)-(-)-1-Phenyl-1,2-Ethanediol is a high-purity chiral diol and a valuable building block in asymmetric synthesis. This compound matters as a versatile intermediate for producing optically active pharmaceuticals, agrochemicals, and specialty materials. Industries that need it include pharmaceutical R&D, fine chemical manufacturing, and academic research laboratories focusing on chiral chemistry and catalysis.

Application

• Chiral Ligand and Catalyst Synthesis: A key precursor for the preparation of enantioselective catalysts and auxiliaries used in asymmetric hydrogenation and carbon-carbon bond-forming reactions.
• Pharmaceutical Intermediates: Serves as a critical starting material or intermediate in the synthesis of active pharmaceutical ingredients (APIs) with defined stereochemistry, particularly for CNS and cardiovascular drugs.
• Agrochemical Synthesis: Used in the production of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Flavor and Fragrance Industry: Employed as a chiral synthon for the synthesis of stereodefined aroma chemicals and natural product analogs.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of chiral polymers and advanced functional materials.
• Academic and Process Chemistry: A standard compound for methodological development in stereoselective synthesis and scale-up process optimization studies.

Basic Information

Product Name	(R)-(-)-1-Phenyl-1,2-Ethanediol
CAS No.	16355-00-3
Molecular Formula	C8H10O2
Molecular Weight	138.16 g/mol
Synonyms	(R)-(-)-1-Phenylethane-1,2-diol; (R)-1-Phenyl-1,2-ethanediol; (R)-Styrene Glycol; (R)-1-Phenylethylene Glycol; (R)-(-)-1-Phenyl-1,2-dihydroxyethane; (R)-1,2-Dihydroxy-1-phenylethane; (R)-Phenylglycol; (R)-Mandelic Alcohol
EINECS	Contact for details

Quality Control

Our (R)-(-)-1-Phenyl-1,2-Ethanediol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for research and industrial use. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) and specific optical rotation values are provided to guarantee identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	92 - 96 °C
Specific Optical Rotation	-40° to -44° (c=1 in ethanol)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.