Description

1,2-Benzisoxazole-5-Sulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a sulfonylation reagent, facilitating the introduction of the sulfonyl functional group into target molecules with high efficiency. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides that require the benzisoxazole sulfonyl moiety for bioactivity.
• Material Science: Building block for creating specialized polymers and functional materials with specific sulfonyl group properties.
• Chemical Research: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Dye and Pigment Industry: Intermediate in the production of specialized sulfonated colorants.

Basic Information

Product Name	1,2-Benzisoxazole-5-Sulfonyl Chloride
CAS No.	16331-62-7
Molecular Formula	C7H4ClNO3S
Molecular Weight	217.63 g/mol
Synonyms	5-Chlorosulfonyl-1,2-benzisoxazole; 1,2-Benzisoxazole-5-sulfonyl chloride; Benzisoxazole-5-sulfonyl chloride; 5-(Chlorosulfonyl)-1,2-benzisoxazole; 1,2-Benzisoxazol-5-ylsulfonyl chloride; 5-Sulfonyl chloride benzisoxazole; 2,1-Benzisoxazole-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1,2-Benzisoxazole-5-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed on every batch. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.