Description

1,2-Dihydrocyclopenta[B]Indol-3(4H)-One is a polycyclic heteroaromatic ketone featuring a fused indole–cyclopentanone scaffold, widely recognized for its structural relevance in medicinal chemistry and organic synthesis. This compound serves as a privileged building block for the development of bioactive molecules, particularly in CNS-targeted drug discovery and kinase inhibitor programs. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in high-value intermediate synthesis. The compound is commercially available as 1,2-Dihydrocyclopenta[B]Indol-3(4H)-One CAS NO 16244-15-8.

Application

• Key synthetic intermediate in the preparation of indole-based serotonin receptor modulators and antipsychotic candidates
• Core scaffold for structure–activity relationship (SAR) studies targeting phosphodiesterase (PDE) and cyclin-dependent kinase (CDK) inhibitors
• Building block in multistep syntheses of natural product analogues, including modified ergot alkaloid derivatives
• Substrate for transition-metal-catalyzed C–H functionalization to access diversely substituted tricyclic indolinones
• Reference standard in analytical method development for LC-MS/MS quantification in preclinical pharmacokinetic studies
• Material for solid-phase combinatorial library synthesis under mild coupling conditions

Basic Information

Product Name	1,2-Dihydrocyclopenta[B]Indol-3(4H)-One
CAS No.	16244-15-8
Molecular Formula	C13H11NO
Molecular Weight	197.23 g/mol
Synonyms	1,2-Dihydrocyclopenta[b]indol-3(4H)-one; 3-Oxo-1,2,3,4-tetrahydrocyclopenta[b]indole; THCP-Indolone; CPBIO; Cyclopenta[b]indol-3(4H)-one, 1,2-dihydro-; 1,2-Dihydro-3H-cyclopenta[b]indol-3-one; NSC 121572; Indolo[2,3-b]cyclopentan-3-one, 1,2-dihydro-
EINECS	Not listed (not notified under EINECS)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent purity requirements for research-grade intermediates and are tested per ICH Q2(R2) guidelines. Analytical validation includes identity confirmation (IR, HPLC retention time match), assay (HPLC area normalization), and impurity profiling (related substances by HPLC). The material meets specifications for residual solvents (ICH Q3C) and heavy metals (ICH Q3D).

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its light-sensitive nature, avoid prolonged exposure to ambient or UV light during handling and dispensing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	≤ 1.0% total impurities
Single Impurity	≤ 0.3%
Residue on Ignition	≤ 0.1%
Water (KF)	≤ 0.5%
Solubility	Soluble in DCM, DMF, THF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.