Description

(20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnane CAS NO 16134-56-8 is a high-purity, organosilicon-protected pregnane derivative, a critical advanced intermediate in the synthesis of complex steroid-based pharmaceuticals. Its primary value lies in providing a stable, reactive platform for the controlled introduction of functional groups at the 3 and 20 positions of the steroid nucleus. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those focused on developing novel corticosteroids, hormone modulators, and other bioactive steroid molecules.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the multi-step production of active pharmaceutical ingredients (APIs) with corticosteroid or hormonal activity.
• Steroid Research & Development: Used in academic and industrial R&D for exploring new steroid derivatives and studying structure-activity relationships (SAR).
• Fine Chemical Synthesis: Serves as a building block for creating specialized, high-value steroid compounds used in biochemical research and diagnostics.
• Process Chemistry: Employed in route scouting and optimization for the scalable manufacturing of steroid-based drugs.
• Reference Standard: Can be utilized as a chromatographic or spectroscopic standard for quality control in steroid manufacturing processes.

Basic Information

Item	Details
Product Name	(20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnane
CAS No.	16134-56-8
Molecular Formula	C29H54O2Si2
Molecular Weight	490.91 g/mol
Synonyms	5β-Pregnane-3α,20-diol bis(trimethylsilyl) ether; (20S)-3α,20-Bis[(trimethylsilyl)oxy]-5β-pregnane; 3α,20β-Bis(trimethylsiloxy)-5β-pregnane; Pregnane-3,20-diol bis-TMS ether; 5β-Pregnane-3α,20α-diol bis(trimethylsilyl) ether; 16134-56-8; Steroid TMS derivative
EINECS	Contact for details

Quality Control

Our (20S)-3α,20-Bis(Trimethylsiloxy)-5β-Pregnane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can compromise product stability. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.