Description

Bis(4-(Trifluoromethyl)Phenyl)Phosphine Oxide is a high-value organophosphorus compound featuring electron-withdrawing trifluoromethyl groups, which significantly influence its reactivity and physical properties. This compound is a critical intermediate and ligand precursor in advanced chemical synthesis, particularly valued for its role in facilitating challenging coupling and catalytic reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require sophisticated building blocks for drug discovery and high-performance polymer development.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Catalyst Ligand Precursor: Used to generate specialized phosphine ligands for transition metal catalysis, including cross-coupling reactions (e.g., Suzuki, Heck) critical for forming carbon-carbon bonds.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides where the trifluoromethyl group imparts desired biological activity and environmental persistence.
• Material Science Research: Acts as a monomer or additive in the development of fluorinated polymers and advanced materials with unique thermal, chemical, or optical properties.
• Organic Electronics: Investigated for use in the synthesis of components for organic light-emitting diodes (OLEDs) and semiconductors due to its electron-deficient character.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	Bis(4-(Trifluoromethyl)Phenyl)Phosphine Oxide
CAS No.	15929-43-8
Molecular Formula	C14H8F6OP
Molecular Weight	346.18 g/mol
Synonyms	Bis[4-(Trifluoromethyl)phenyl]phosphine Oxide; Di(4-Trifluoromethylphenyl)phosphine Oxide; Phosphine Oxide, Bis[4-(Trifluoromethyl)phenyl]-; 4,4'-(Oxophosphanylidene)bis(α,α,α-trifluorotoluene); α,α,α,α',α',α'-Hexafluoro-4,4'-methylenediphosphine Oxide Derivative; (4-(Trifluoromethyl)phenyl)phosphinic Acid Bis(4-(Trifluoromethyl)phenyl) Ester (tautomeric form); Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our Bis(4-(Trifluoromethyl)Phenyl)Phosphine Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.