Description

Progesterone-D9 is a stable isotope-labeled analog of progesterone, where nine hydrogen atoms are replaced by deuterium. This high-purity internal standard is critical for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly mass spectrometry. It is an essential tool for pharmaceutical research, clinical diagnostics, and forensic toxicology laboratories requiring precise measurement of progesterone levels in complex biological matrices.

Application

• Quantitative Mass Spectrometry: Serves as a primary internal standard for the LC-MS/MS and GC-MS analysis of endogenous progesterone in serum, plasma, and tissue samples.
• Pharmacokinetic & Bioequivalence Studies: Enables accurate tracking of exogenous progesterone drug absorption, distribution, metabolism, and excretion (ADME) in clinical trials.
• Endocrine Disorder Diagnostics: Used in clinical assay development and validation for conditions related to progesterone imbalance, such as infertility and luteal phase defects.
• Doping Control & Forensic Analysis: Facilitates the definitive identification and quantification of progesterone and related progestins in anti-doping and forensic investigations.
• Method Development & Validation: Provides a stable, non-interfering reference compound for developing robust analytical methods with high precision and low matrix effects.
• Metabolite Tracing Studies: Allows for the detailed study of progesterone metabolic pathways in research settings using isotope tracing techniques.

Basic Information

Product Name	Progesterone-D9
CAS No.	15775-74-3
Molecular Formula	C21H21D9O2
Molecular Weight	323.50 g/mol
Synonyms	Pregn-4-ene-3,20-dione-17α,21,21,21-d4-11,12,19,19,19-d5; Deuterated Progesterone; [17α,21,21,21,11,12,19,19,19-d9]-Progesterone; 4-Pregnene-3,20-dione-d9; Progesterone (D9); Progesterone-d9 Internal Standard; d9-Progesterone
EINECS	Contact for details

Quality Control

Our Progesterone-D9 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, which are paramount for analytical accuracy. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and confirmation of structure. We adhere to relevant standards for high-purity reference materials to support GLP and ISO 17025 compliant laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is easily oxidized and should be handled under an inert atmosphere when appropriate. For long-term storage, consider storage at -20°C under nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Purity	≥98 atom % D
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.