Description

L-n-Tau-Methyl-D3-Histidine is a stable isotope-labeled derivative of the amino acid histidine, specifically deuterated at three positions. This compound is a critical tool for advanced analytical research, enabling precise quantification and metabolic pathway tracing through mass spectrometry. It is primarily utilized by pharmaceutical researchers, academic institutions, and contract research organizations (CROs) engaged in proteomics, metabolomics, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate measurement of histidine and related metabolites.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate histidine metabolism, protein synthesis rates, and turnover in biological systems.
• Proteomics Research: Employed in the development and validation of targeted proteomic assays for biomarker discovery and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Facilitates the study of the absorption, distribution, metabolism, and excretion (ADME) of drug candidates.
• Clinical Diagnostics: Potential use in developing high-precision diagnostic tests for inborn errors of metabolism related to histidine.
• Nutritional Science Research: Applied in studies investigating protein metabolism, requirements, and the role of histidine in human health.

Basic Information

Product Name	L-n-Tau-Methyl-D3-Histidine
CAS No.	15507-76-3
Molecular Formula	C10H14D3N3O3S
Molecular Weight	256.31 g/mol
Synonyms	L-N(τ)-Methylhistidine-d3; 3-Methyl-L-histidine-d3; 1-Methyl-L-histidine-d3 (tautomer); N(τ)-Methyl-L-histidine-d3; Deuterated L-Methylhistidine; L-Methylhistidine (methyl-d3); (2S)-2-Amino-3-(1-methyl-1H-imidazol-4-yl-d3)propanoic acid; Histidine, N(τ)-methyl-, L-, methyl-d3
EINECS	Contact for details

Quality Control

Our L-n-Tau-Methyl-D3-Histidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and MS, to confirm chemical identity, isotopic purity (D-enrichment), and chemical purity. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.