Description

(14ξ)-5,6-Didehydro-4-Hydroxy-3,6-Dimethoxy-17-Methylmorphinan-7-One CAS NO 15444-27-6 is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard for the synthesis and analytical characterization of complex active pharmaceutical ingredients (APIs). It is essential for research organizations and manufacturers focused on neuropharmacology, analgesic development, and the study of opioid receptor ligands, where precise chemical structure and purity are paramount for reliable results.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for novel therapeutic agents, particularly in the central nervous system (CNS) category.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing via techniques like HPLC, GC-MS, and NMR.
• Biochemical Research: Employed in vitro and in vivo studies to investigate receptor binding affinity, metabolic pathways, and structure-activity relationships (SAR).
• Process Chemistry & Scale-Up: Supports route scouting and optimization for the commercial manufacturing of complex drug substances.
• Academic Research: Facilitates groundbreaking studies in medicinal chemistry and pharmacology at universities and institutional labs.
• Impurity Standard: Critical for identifying, quantifying, and controlling potential genotoxic or process-related impurities in final drug products.

Basic Information

Product Name	(14ξ)-5,6-Didehydro-4-Hydroxy-3,6-Dimethoxy-17-Methylmorphinan-7-One
CAS No.	15444-27-6
Molecular Formula	C₁₉H₂₅NO₄
Molecular Weight	331.41 g/mol
Synonyms	4,14-Dihydroxy-3,6-dimethoxy-17-methyl-6,7-didehydromorphinan; 4-Hydroxy-3,6-dimethoxy-17-methyl-5,6-didehydromorphinan-7-one; 7-Oxomorphinan derivative; Noroxymorphone derivative; 14-Hydroxy-3,6-dimethoxy-17-methyl-5,6-didehydromorphinan-7-one; Morphinan-7-one, 5,6-didehydro-4-hydroxy-3,6-dimethoxy-17-methyl-, (14ξ)-
EINECS	Contact for details

Quality Control

Every batch of (14ξ)-5,6-Didehydro-4-Hydroxy-3,6-Dimethoxy-17-Methylmorphinan-7-One is manufactured under a strict quality management system. We provide comprehensive analytical documentation to ensure traceability and compliance with your research or cGMP guidelines. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profile as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.