Description

2H-Spiro[Isoquinoline-1,4'-Piperidine]-3(4H)-One is a high-value, complex heterocyclic compound featuring a unique spirocyclic architecture that combines isoquinoline and piperidine motifs. This structural complexity makes it a critical advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams focused on developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a privileged scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Alkaloid Synthesis: Acts as a sophisticated building block for the synthesis of complex natural product analogs and alkaloid derivatives.
• Ligand Development: Utilized in the development of novel ligands for receptors and enzymes, facilitating drug discovery programs.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Academic & Industrial R&D: Essential for research institutions and CROs (Contract Research Organizations) engaged in innovative organic synthesis.

Basic Information

Item	Details
Product Name	2H-Spiro[Isoquinoline-1,4'-Piperidine]-3(4H)-One
CAS No.	15142-87-7
Molecular Formula	C13H14N2O
Molecular Weight	214.26 g/mol
Synonyms	1,4-Dihydro-2H-spiro[isoquinoline-1,4'-piperidin]-3-one; 2H-Spiro(isoquinoline-1,4'-piperidin)-3(4H)-one; Spiro[isoquinoline-1(2H),4'-piperidin]-3-one; 1,4-Dihydrospiro[isoquinoline-1,4'-piperidin]-3-one; 3-Oxo-1,4-dihydro-2H-spiro[isoquinoline-1,4'-piperidine]; Spiro[Isoquinoline-1,4'-Piperidine]-3(4H)-One
EINECS	Contact for details

Quality Control

Our 2H-Spiro[Isoquinoline-1,4'-Piperidine]-3(4H)-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.