Description

2-Methoxy-4,4,5,5-Tetramethyl-[1,3,2]-Dioxaphospholane is a specialized organophosphorus compound, specifically a cyclic phosphite ester, with the CAS number 14812-60-3. It serves as a crucial intermediate and reagent in advanced organic synthesis, particularly valued for its role in phosphorylation and as a precursor to phosphonates and phosphoramidites. This chemical is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, where it is used to develop active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, prodrugs, and other bioactive molecules requiring phosphorus incorporation.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators that utilize phosphonate or phosphite chemistry.
• Ligand Precursor: Serves as a starting material for creating chiral and achiral phosphine ligands used in catalysis, such as cross-coupling reactions.
• Polymer Modification: Employed in the synthesis of flame-retardant additives or as a monomer for creating phosphorus-containing polymers with specialized properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new phosphorylation methodologies and creating novel organophosphorus compounds.
• Material Science: Used in surface modification and the development of advanced materials, including those for electronics and coatings.

Basic Information

Product Name	2-Methoxy-4,4,5,5-Tetramethyl-[1,3,2]-Dioxaphospholane
CAS No.	14812-60-3
Molecular Formula	C7H15O3P
Molecular Weight	178.17 g/mol
Synonyms	2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; 4,4,5,5-Tetramethyl-2-methoxy-1,3,2-dioxaphospholane; Methyl 4,4,5,5-tetramethyl-1,3,2-dioxaphospholane-2-oxide; 2-Methoxy-2-oxo-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; Cyclic methyl phosphite (tetramethyl substituted); TMDP (abbreviation); Tetramethyl methylenediphosphonate cyclic ester
EINECS	Contact for details

Quality Control

Our 2-Methoxy-4,4,5,5-Tetramethyl-[1,3,2]-Dioxaphospholane is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C to maximize stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.