Description

2-Chloro-4,4,5,5-Tetramethyl-1,3,2-Dioxaphospholane is a specialized organophosphorus compound, specifically a cyclic chlorophosphite ester, that serves as a crucial reagent in advanced synthetic chemistry. Its primary value lies in its role as a versatile phosphorylating and coupling agent, enabling the synthesis of complex molecules with high precision and efficiency. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating nucleoside phosphoramidites and other prodrugs, critical in antiviral and anticancer drug development.
• Agrochemical Production: Used in the synthesis of novel phosphate and phosphorothioate ester pesticides and herbicides, enhancing crop protection.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of flame-retardant polymers and specialty polyphosphoesters with tailored properties.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral phosphite and phosphoramidite ligands used in asymmetric catalysis.
• Nucleic Acid Chemistry: Employed in oligonucleotide synthesis, particularly for the preparation of modified DNA/RNA backbones for research and therapeutic applications.
• Surface Modification: Used to functionalize surfaces and nanoparticles with phosphate groups for biomedical and sensor applications.

Basic Information

Item	Detail
Product Name	2-Chloro-4,4,5,5-Tetramethyl-1,3,2-Dioxaphospholane
CAS No.	14812-59-0
Molecular Formula	C6H12ClO2P
Molecular Weight	182.59 g/mol
Synonyms	2-Chloro-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; 2-Chloro-2-oxo-4,4,5,5-tetramethyl-1,3,2-dioxaphospholane; Tetramethyl ethylene chlorophosphite; Chloro(4,4,5,5-tetramethyl-1,3,2-dioxaphospholane); 1,3,2-Dioxaphospholane, 2-chloro-4,4,5,5-tetramethyl-; Phosphorochloridous acid, cyclic 2,2-dimethyltrimethylene ester
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,4,5,5-Tetramethyl-1,3,2-Dioxaphospholane is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency suitable for research and industrial-scale applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its sensitivity to moisture and strong acids/organic solvents, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Chloride Content	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.