Description

Propionic-2,2-D2 Acid is a deuterium-labeled isotopologue of propionic acid, where two hydrogen atoms at the 2-position are replaced with deuterium (CAS NO 14770-51-5). This isotopic labeling is critical for applications requiring precise molecular tracing and spectroscopic studies without altering the fundamental chemical behavior. It is an essential material for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, stable-isotope labeled compounds for analytical and synthetic purposes.

Application

• Internal Standard for Mass Spectrometry (MS): Used as a quantitative internal standard in GC-MS and LC-MS analysis for accurate measurement of propionic acid and related metabolites in complex biological and environmental matrices.
• Metabolic Pathway Tracing: Serves as a crucial tracer in metabolic flux analysis and pharmacokinetic studies to elucidate biochemical pathways and drug metabolism mechanisms.
• NMR Spectroscopy Solvent & Reagent: Employed as a deuterated reagent or solvent component in Nuclear Magnetic Resonance (NMR) spectroscopy to simplify spectra and avoid signal interference from protons.
• Pharmaceutical Intermediate: Acts as a labeled building block in the synthesis of deuterated active pharmaceutical ingredients (APIs), which can offer improved metabolic stability and pharmacokinetic profiles.
• Agrochemical Research: Utilized in the development and environmental fate studies of deuterated pesticides and herbicides.
• Polymer & Material Science: Applied in the research of deuterated polymers and organic electronic materials to study structure-property relationships and dynamics.

Basic Information

Product Name	Propionic-2,2-D2 Acid
CAS No.	14770-51-5
Molecular Formula	C3D2H4O2
Molecular Weight	76.09 g/mol
Synonyms	Deuterated Propionic Acid; [2,2-2H2]Propanoic Acid; Propionic Acid-d2; 2,2-Dideuteropropanoic Acid; Propanoic-2,2-d2 Acid; Dideuteropropionic Acid; Ethane-1,1-d2-carboxylic Acid; Methylmalonic Acid-d2 (decarboxylation related)
EINECS	Contact for details

Quality Control

Our Propionic-2,2-D2 Acid is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and isotopic enrichment. We provide detailed Certificates of Analysis (COA) that include data for identity, assay, isotopic purity (D-enrichment), and specific impurity profiles via techniques such as NMR, MS, and HPLC. Our quality commitment aligns with the needs of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its nature as a strong acid/organic solvent, it should be stored separately from incompatible materials such as strong bases, oxidizing agents, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.