Description

Dimethyl Adipimidate Dihydrochloride is a bifunctional cross-linking reagent primarily used for protein modification and structural studies. This compound matters for its ability to introduce covalent bonds between primary amines under mild aqueous conditions, preserving biological activity. It is essential for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and proteomics, where precise protein structure-function analysis is critical.

Application

• Bioconjugation and Protein Cross-linking: Used to covalently link proteins, peptides, or other amine-containing molecules for structural stabilization or complex formation.
• Antibody-Drug Conjugate (ADC) Development: Serves as a linker precursor or reagent in the synthesis of stable, cleavable linkers connecting cytotoxic payloads to monoclonal antibodies.
• Proteomics and Structural Biology: A key tool for studying protein-protein interactions, protein folding, and three-dimensional structure through chemical cross-linking mass spectrometry (XL-MS).
• Enzyme and Receptor Immobilization: Facilitates the attachment of bioactive molecules to solid supports for biosensor development, diagnostic assays, and affinity chromatography.
• Material Surface Functionalization: Used to introduce amine-reactive groups onto polymers, nanoparticles, or other materials for subsequent biomolecule attachment.
• Pharmaceutical Intermediate: Acts as a building block in the synthesis of more complex therapeutic agents and diagnostic compounds.

Basic Information

Product Name	Dimethyl Adipimidate Dihydrochloride
CAS No.	14620-72-5
Molecular Formula	C8H18N2O2 • 2HCl
Molecular Weight	255.16 g/mol
Synonyms	Adipimidic Acid Dimethyl Ester Dihydrochloride; Dimethyl Adipimidate • 2HCl; DMA • 2HCl; Dimethyl Adipimidate Hydrochloride; N,N'-Dimethyladipimidate Dihydrochloride; Bis(methyl imidate) Adipate Dihydrochloride; Adipic Acid Bis(methylimidate) Dihydrochloride; 1,6-Dimethyl Adipimidate Dihydrochloride
EINECS	Contact for details

Quality Control

Our Dimethyl Adipimidate Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and precise water content determination. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Solubility	Soluble in water, methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.