Description

3-(Trifluoroacetyl)Indole is a versatile and high-value fluorinated indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its core value lies in the trifluoroacetyl group, which acts as a powerful directing and activating moiety for constructing complex heterocyclic systems. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides with improved efficacy and environmental profiles.
• Material Science Research: Serves as a precursor for creating novel fluorinated organic electronic materials and liquid crystals.
• Complex Molecule Construction: Employed in medicinal chemistry for the efficient synthesis of complex indole-based alkaloids and other natural product analogs.
• Fluorine Chemistry Studies: A valuable reagent for investigating the effects of fluorine substitution on molecular reactivity and biological activity.

Basic Information

Product Name	3-(Trifluoroacetyl)Indole
CAS No.	14618-45-2
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	1H-Indole-3-carboxaldehyde, 2,2,2-trifluoro-1-oxoethyl-; 3-(2,2,2-Trifluoroacetyl)-1H-indole; 1-(1H-Indol-3-yl)-2,2,2-trifluoroethanone; 3-Trifluoroacetylindole; α,α,α-Trifluoro-1H-indole-3-acetaldehyde; 2,2,2-Trifluoro-1-(1H-indol-3-yl)ethanone
EINECS	Contact for details

Quality Control

Our 3-(Trifluoroacetyl)Indole is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.