Description

5-Amino-Thiophene-2-Carboxylic Acid Methyl Ester is a versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its bifunctional structure, featuring both a reactive amino group and an ester moiety on a thiophene scaffold, enabling its use in the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, serving as a key precursor for active pharmaceutical ingredients (APIs), functional dyes, and advanced polymers.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the thiophene core contributes to biological activity.
• Material Science & Organic Electronics: Serves as a monomer or precursor for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials.
• Dye & Pigment Manufacturing: Functions as an intermediate in the synthesis of specialized dyes, pigments, and fluorescent markers.
• Chemical Research & Development: Employed as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Coordination Chemistry: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalytic complexes due to its nitrogen and sulfur donor atoms.

Basic Information

Item	Detail
Product Name	5-Amino-Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	14597-58-1
Molecular Formula	C6H7NO2S
Molecular Weight	157.19 g/mol
Synonyms	Methyl 5-Aminothiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-amino-, methyl ester; 5-Amino-2-thiophenecarboxylic acid methyl ester; Methyl 5-amino-2-thiophenecarboxylate; 5-Amino-2-(methoxycarbonyl)thiophene; 5-Aminothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our production of 5-Amino-Thiophene-2-Carboxylic Acid Methyl Ester adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates. Our quality commitment guarantees material consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent oxidation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.