Description

2-Bromo-4-Methyl-Benzothiol is a specialized organosulfur compound featuring a bromine substituent, serving as a versatile building block in advanced organic synthesis. Its value lies in its dual functionality, where the thiol group acts as a potent nucleophile and the bromine atom provides a handle for further cross-coupling reactions, enabling the construction of complex molecular architectures. This intermediate is particularly needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting neurological disorders and oncology.
• Agrochemical Synthesis: Used in the development of new-generation pesticides and herbicides, leveraging its reactive sites for structural diversification.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis.
• Material Science Research: Employed in the creation of functionalized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Utilized to develop activity-based probes for studying enzyme mechanisms and protein functions.
• Custom Synthesis and Contract Manufacturing: A critical reagent for custom synthesis houses serving the fine chemical and life science industries.

Basic Information

Product Name	2-Bromo-4-Methyl-Benzothiol
CAS No.	14395-53-0
Molecular Formula	C8H7BrS
Molecular Weight	215.11 g/mol
Synonyms	2-Bromo-4-methylbenzenethiol; 4-Methyl-2-bromobenzenethiol; 2-Bromo-p-toluenethiol; (2-Bromo-4-methylphenyl)thiol; 1-Bromo-2-mercapto-5-methylbenzene; Benzothiol, 2-bromo-4-methyl-; 14395-53-0; 2-Bromo-4-methylthiophenol
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Methyl-Benzothiol is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and reactivity with strong acids and oxidizing agents, the container must be kept sealed under an inert atmosphere (e.g., nitrogen) to prevent degradation and oxidation of the thiol group. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.