Description

Diprenorphine is a potent opioid antagonist of significant importance in pharmaceutical research and veterinary medicine. Its primary value lies in its high-affinity binding to opioid receptors, making it a critical tool for reversing the effects of potent opioids like etorphine. This compound is essential for researchers in neuropharmacology and for veterinary professionals managing large animal anesthesia, where rapid reversal is a safety necessity.

Application

• Veterinary Anesthesia Reversal: Primary agent for reversing the effects of etorphine (M99) in large animal immobilization, crucial for wildlife management and veterinary surgery.
• Pharmacological Research: Used as a standard reference antagonist in studies investigating opioid receptor function, signaling pathways, and drug interactions.
• Neuropharmacology: A key tool for blocking opioid effects in experimental models of pain, addiction, and neuropsychiatric disorders.
• Analytical Standard: Serves as a high-purity reference standard in HPLC, LC-MS, and other analytical methods for quality control and forensic analysis.
• Biochemical Assay Development: Utilized in the development and validation of receptor binding assays and other in vitro test systems.
• Toxicology Studies: Employed in research focused on opioid overdose mechanisms and the development of novel treatment strategies.

Basic Information

Product Name	Diprenorphine
CAS No.	14357-78-9
Molecular Formula	C26H35NO4
Molecular Weight	425.56 g/mol
Synonyms	Diprenorphine; M5050; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (5α,7α)-; 17-Cyclopropylmethyl-4,5α-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α,7α-dimethyl-6,14-ethenomorphinan-7-methanol; Reckitt 5050; Buprenorphine Impurity C (Diprenorphine); N-Cyclopropylmethyl-6,14-etheno-7α-(1-hydroxy-1-methylethyl)-6,7,8,14-tetrahydrooripavine
EINECS	Contact for details

Quality Control

Our Diprenorphine is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research and veterinary applications. Each lot undergoes comprehensive analytical testing, including HPLC purity assay, identity confirmation by spectroscopic methods, and stringent control of related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our rigorous in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.