Description

D-Glutamic-2,3,3,4,4-D5 Acid is a high-purity, stable isotope-labeled derivative of D-glutamic acid, where five hydrogen atoms are replaced by deuterium at specific positions. This compound is essential for advanced analytical research, providing a critical internal standard for precise quantification and metabolic pathway tracing using techniques like mass spectrometry and NMR. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and contract research organizations (CROs) focused on metabolomics, pharmacokinetics, and stable isotope probing studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical quantitative reference in LC-MS and GC-MS analyses for accurate measurement of endogenous glutamic acid and related metabolites in complex biological matrices.
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) to track and elucidate metabolic fluxes and biochemical pathways in cell cultures, tissues, or whole organisms.
• Pharmacokinetic and Drug Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) when incorporated into drug candidates or used as an analytical standard.
• NMR Spectroscopy: Acts as a valuable probe in nuclear magnetic resonance studies due to the distinct signal properties of deuterium, aiding in structural and dynamic analysis of biomolecules.
• Biochemical Research: Supports investigations into glutamate receptor function, neurotransmitter dynamics, and amino acid metabolism in neurological and physiological research.
• Quality Control in Pharmaceutical Manufacturing: Can be employed as a reference standard in the quality assurance of pharmaceutical products and raw materials involving glutamic acid or its derivatives.

Basic Information

Item	Details
Product Name	D-Glutamic-2,3,3,4,4-D5 Acid
CAS No.	14341-88-9
Molecular Formula	C5H4D5NO4
Molecular Weight	156.16 g/mol (for deuterated form)
Synonyms	(2R)-2-Aminopentanedioic-2,3,3,4,4-d5 Acid; D-Glutamic Acid-d5; (R)-2-Aminopentanedioic-2,3,3,4,4-d5 Acid; Deuterated D-Glutamic Acid; D-Glutamate-d5; (R)-Glutamic-2,3,3,4,4-d5 Acid; Stable Isotope Labeled D-Glutamic Acid
EINECS	Contact for details

Quality Control

Our D-Glutamic-2,3,3,4,4-D5 Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, isotopic enrichment, and structural integrity. Standard analyses include HPLC for chemical purity, NMR and MS for isotopic purity and positional deuterium incorporation verification. Certificates of Analysis (COA) detailing all specifications and test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98 atom % D
Positional Deuterium Enrichment (NMR)	≥ 95% at each labeled position (2,3,3,4,4)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.