Description

n-Acetyl-D-Glutamic-2,3,3,4,4-D5 Acid is a high-purity, deuterium-labeled derivative of N-Acetyl-D-glutamic acid, serving as a critical stable isotope-labeled internal standard. This compound is essential for ensuring accuracy and reliability in quantitative mass spectrometry analyses, particularly in complex biological matrices. It is primarily utilized by research scientists and quality control laboratories in the pharmaceutical, biotechnology, and metabolomics sectors for advanced analytical method development and validation.

Application

• Mass Spectrometry Internal Standard: Used as a stable isotope-labeled reference compound for the precise quantification of N-Acetyl-D-glutamic acid and related metabolites in LC-MS/MS and GC-MS applications.
• Pharmaceutical Research: Critical for pharmacokinetic (PK) and pharmacodynamic (PD) studies, enabling accurate tracking of drug metabolites and understanding metabolic pathways.
• Metabolomics & Biomarker Discovery: Facilitates high-fidelity profiling of glutamic acid derivatives in biological samples (e.g., plasma, urine, tissue) for disease research.
• Deuterated Compound Synthesis: Acts as a key chiral building block for the synthesis of more complex deuterium-labeled molecules in medicinal chemistry.
• Quality Control & Method Validation: Employed in analytical laboratories to validate assay methods, ensuring compliance with regulatory standards like GLP and GMP.
• Nutritional & Biochemical Studies: Supports research into amino acid metabolism, neurotransmitter pathways, and related biochemical mechanisms.

Basic Information

Product Name	n-Acetyl-D-Glutamic-2,3,3,4,4-D5 Acid
CAS No.	14341-87-8
Molecular Formula	C7H6D5NO5
Molecular Weight	~194.18 g/mol
Synonyms	N-Acetyl-D-glutamic-2,3,3,4,4-d5 Acid; (2R)-2-Acetamidopentanedioic-2,3,3,4,4-d5 Acid; Deuterated N-Acetyl-D-glutamic Acid; N-Acetyl-D-glutamic Acid-d5; Ac-D-Glu-d5-OH; D-N-Acetylglutamic Acid-d5; Stable Isotope Labeled N-Acetyl-D-glutamate
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-D-Glutamic-2,3,3,4,4-D5 Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality commitment includes comprehensive characterization by NMR, MS, and HPLC to verify isotopic enrichment and chemical purity, meeting the stringent requirements for research and analytical applications. Certificates of Analysis (COA) detailing batch-specific results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.