Description

L-Glutamine-2,3,3,4,4-D5 is a stable isotope-labeled analog of the essential amino acid L-glutamine, specifically deuterated at five positions. This high-purity compound is critical for advanced research requiring precise metabolic tracing and quantification in complex biological systems. It is primarily utilized by researchers and analytical laboratories in the fields of pharmaceutical development, metabolomics, and nutritional science for applications such as mass spectrometry, NMR spectroscopy, and stable isotope-resolved metabolic flux analysis.

Application

• Biomedical Research & Metabolomics: Used as an internal standard for the accurate quantification of endogenous L-glutamine levels in biological samples via LC-MS or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in tracer studies to investigate the metabolic pathways and pharmacokinetic profiles of new drug candidates.
• Nutritional Science: Facilitates research into glutamine metabolism, uptake, and utilization in various tissues under different physiological and pathological conditions.
• Proteomics & Cell Culture: Used in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other labeling techniques for protein turnover and synthesis studies.
• Clinical Diagnostics Development: Serves as a critical reference standard in the development of diagnostic assays for metabolic disorders.

Basic Information

Product Name	L-Glutamine-2,3,3,4,4-D5
CAS No.	14341-78-7
Molecular Formula	C5H5D5N2O3
Molecular Weight	151.18 g/mol
Synonyms	(2S)-2-Amino-4-carbamoyl-2,3,3,4,4-pentadeuteriobutanoic acid; L-Glutamine-d5; Glutamine-2,3,3,4,4-d5; (S)-2,5-Diamino-2,3,3,4,4-pentadeuterio-5-oxopentanoic acid; GLN-d5; 2-Aminoglutaramic acid-d5; Levoglutamide-d5
EINECS	Contact for details

Quality Control

Our L-Glutamine-2,3,3,4,4-D5 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment, chemical purity, and chiral purity. We adhere to relevant industry standards for high-purity reference materials to guarantee reliable and reproducible results in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Optical Rotation	[α]D20: +6.0° to +8.0° (c=2 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.