Description

(R)-3-Methyl 3,4-Dihydroisoquinoline Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry and isoquinoline core structure make it a critical precursor in the synthesis of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is essential for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of central nervous system (CNS) agents, alkaloid-based therapeutics, and other bioactive molecules.
• Asymmetric Synthesis: Serves as a versatile starting material or ligand precursor in catalytic asymmetric reactions due to its (R)-configured stereocenter.
• Agrochemical Research: Used in the synthesis of novel chiral compounds for crop protection and pesticide development.
• Academic & Industrial R&D: A valuable reagent for medicinal chemistry programs and process chemistry optimization in laboratory and pilot-scale settings.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring high isomeric purity.

Basic Information

Product Name	(R)-3-Methyl 3,4-Dihydroisoquinoline Hydrochloride
CAS No.	14123-78-5
Molecular Formula	C10H12ClN
Molecular Weight	181.66 g/mol
Synonyms	(R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline hydrochloride; (R)-3-Methyl-3,4-dihydro-1H-isoquinoline hydrochloride; (R)-3-Methyl-THIQ HCl; (R)-3-Methyl-1,2,3,4-tetrahydroisoquinoline HCl; (R)-3-Me-THIQ hydrochloride; (R)-3-Methyl-3,4-dihydroisoquinoline HCl; (R)-3-Methyl-3,4-dihydroisoquinolinium chloride
EINECS	Contact for details

Quality Control

Our (R)-3-Methyl 3,4-Dihydroisoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccated environment after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.