Description

Chloro(Diethylamino)-Ethoxyphosphine is a versatile organophosphorus reagent primarily used as a key intermediate in chemical synthesis. Its value lies in its ability to act as a phosphorylating and chlorinating agent, facilitating the construction of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity building blocks for advanced synthesis.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for nucleotide analogs and other phosphorus-containing drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators where phosphorus-based chemistry is required.
• Ligand and Catalyst Preparation: Serves as a starting material for the synthesis of specialized phosphine ligands used in homogeneous catalysis and cross-coupling reactions.
• Flame Retardant Chemistry: An intermediate in the development of organophosphorus flame retardants and plasticizers for polymer applications.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel phosphorus compounds.
• Material Science: Used in the surface modification of materials and the synthesis of phosphorus-containing polymers and coatings.

Basic Information

Product Name	Chloro(Diethylamino)-Ethoxyphosphine
CAS No.	14114-77-3
Molecular Formula	C6H15ClNOP
Molecular Weight	183.61 g/mol
Synonyms	Chloro(diethylamino)ethoxyphosphine; Diethylamino(chloro)ethoxyphosphine; Ethyl Phosphoramidochloridite; (Diethylamino)chloroethoxyphosphine; NSC 163046; Phosphoramidous dichloride, (diethylamino)ethoxy-; (Diethylamino)ethoxyphosphonous dichloride; Chloroethoxy(diethylamino)phosphine
EINECS	Contact for details

Quality Control

Our Chloro(Diethylamino)-Ethoxyphosphine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C (refrigerated) or as specified on the label. Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Diethylamine Content	≤ 1.0%
Chloroethane Content	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.