Description

Sodium Deuteroxide is the deuterated analogue of sodium hydroxide, where the hydrogen atom in the hydroxide group is replaced by deuterium. This compound is a crucial reagent in deuterium labeling and NMR spectroscopy, providing a strong base in deuterated solvents without introducing proton signals. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise deuterium incorporation for kinetic studies, metabolic tracing, or the synthesis of deuterated active pharmaceutical ingredients (APIs).

Application

• Deuterium Labeling in Pharmaceutical Synthesis: Used as a base to introduce deuterium atoms into organic molecules for the development of deuterated drugs, which can offer improved metabolic stability and pharmacokinetic profiles.
• NMR Spectroscopy Solvent Preparation: Essential for adjusting the pD (pH in deuterated systems) of deuterated solvents like DMSO-d6 or D2O to optimize conditions for nuclear magnetic resonance analysis.
• Catalysis and Organic Synthesis: Acts as a strong base in specialized organic reactions conducted in deuterated media, where the exclusion of protons is critical.
• Metabolic Pathway Tracing: Employed in biochemical research to prepare deuterated substrates for studying metabolic pathways and mechanisms using mass spectrometry.
• Materials Science Research: Utilized in the synthesis and modification of polymers or advanced materials where deuterium incorporation is needed to study structure-property relationships via neutron scattering or other analytical techniques.
• Reference Standard Production: Serves as a key ingredient in the preparation of certified reference materials and internal standards for analytical laboratories.

Basic Information

Product Name	Sodium Deuteroxide
CAS No.	14014-06-3
Molecular Formula	NaOD
Molecular Weight	41.00 g/mol (monodeuterated)
Synonyms	Sodium Hydroxide-d; Deuterated Sodium Hydroxide; Sodium Deuteroxide Solution; Sodium Hydroxide (OD); NaOD; Caustic Soda-d; SOD-d
EINECS	237-807-9

Quality Control

Our Sodium Deuteroxide is produced and handled under stringent quality management protocols. Each batch is analyzed to ensure high chemical purity and isotopic enrichment, with key parameters including assay (by titration), deuterium content (by NMR or MS), and limits for critical impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature, store under an inert atmosphere such as argon or nitrogen in a cool, dry place. For solutions, maintain at recommended temperatures (typically 2-8°C for extended stability) and ensure containers are clearly labeled and kept separate from strong acids.

Specification

Item	Specification
Appearance	White solid or clear colorless solution (as specified)
Identification (IR/NMR)	Conforms
Assay (Titration)	≥ 98.0% (basis NaOD)
Deuterium Content (NMR)	≥ 99 atom % D
Water Content (Karl Fischer)	≤ 1.0%
Carbonate (as Na2CO3)	≤ 0.5%
Chloride (Cl)	≤ 0.01%
Sulfate (SO4)	≤ 0.01%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.