Description

2-Bromo-5-Methoxybenzenethiol CAS NO 13993-51-6 is a versatile organosulfur building block characterized by its reactive thiol (-SH) and bromo substituents. This compound is essential for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing sulfur-containing heterocycles and as a key intermediate in cross-coupling reactions.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing benzothiophene or related sulfur heterocycles.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the thiol moiety introduces specific biological activity.
• Material Science: Acts as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for creating biaryl structures.
• Ligand Synthesis: Utilized for preparing sulfur-containing ligands used in catalysis and metal complexation.
• Chemical Research: A valuable reagent in academic and industrial laboratories for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	2-Bromo-5-Methoxybenzenethiol
CAS No.	13993-51-6
Molecular Formula	C7H7BrOS
Molecular Weight	219.10 g/mol
Synonyms	2-Bromo-5-methoxybenzenethiol; 2-Bromo-5-methoxythiophenol; 5-Methoxy-2-bromobenzenethiol; 1-Bromo-4-methoxy-2-mercaptobenzene; (2-Bromo-5-methoxyphenyl)thiol; Benzenethiol, 2-bromo-5-methoxy-; 2-Bromo-5-methoxybenzene-1-thiol
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-5-Methoxybenzenethiol is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) documenting batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.