Description

2-Amino-5-Fluoro-5-(Trifluoromethyl)-4,5-Dihydro-1,3-Thiazol-4-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both amino and trifluoromethyl groups on a thiazolone core, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating new candidates with enhanced properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups can improve metabolic stability and bioavailability.
• Fluorinated Compound Library Synthesis: An essential building block for medicinal chemistry and combinatorial chemistry to create diverse libraries of fluorinated heterocycles for high-throughput screening.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and advanced materials, such as liquid crystals or organic electronic components, due to its electron-deficient character.
• Academic & Contract Research: Employed in university and CRO (Contract Research Organization) laboratories for fundamental research in heterocyclic and fluorine chemistry.

Basic Information

Product Name	2-Amino-5-Fluoro-5-(Trifluoromethyl)-4,5-Dihydro-1,3-Thiazol-4-One
CAS No.	13973-15-4
Molecular Formula	C4H2F4N2OS
Molecular Weight	202.13 g/mol
Synonyms	5-Fluoro-5-(trifluoromethyl)-4,5-dihydro-1,3-thiazol-4-one, 2-amino-; 2-Amino-5-fluoro-5-trifluoromethyl-4,5-dihydro-1,3-thiazol-4-one; 4,5-Dihydro-2-amino-5-fluoro-5-(trifluoromethyl)-1,3-thiazol-4-one; 5-Fluoro-5-(trifluoromethyl)-2-amino-4,5-dihydrothiazol-4-one; 13973-15-4; 2-Amino-5-fluoro-5-(trifluoromethyl)-2-thiazolin-4-one
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-5-Fluoro-5-(Trifluoromethyl)-4,5-Dihydro-1,3-Thiazol-4-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) with supporting chromatographic data (HPLC/GC) is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.