Description

(αs,5α,7α)-α-(1,1-Dimethylethyl)-4,5-Epoxy-3,6-Dimethoxy-α,17-Dimethyl-6,14-Ethenomorphinan-7-Methanol is a complex, high-purity synthetic organic compound belonging to the morphinan class. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of opioid receptor pharmacology. It serves as a critical intermediate or reference standard for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise and reliable chemical building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development, validation, and compound identification via techniques like HPLC and GC-MS.
• Biochemical Research: Employed in pharmacological studies to investigate structure-activity relationships (SAR) and interactions with opioid receptors and related biological pathways.
• Fine Chemical Synthesis: Acts as a specialized building block for the synthesis of complex molecules in medicinal chemistry and custom synthesis projects.
• Academic Research: Utilized in university and institutional labs for advanced organic chemistry research and the development of new synthetic methodologies.

Basic Information

Product Name	(αs,5α,7α)-α-(1,1-Dimethylethyl)-4,5-Epoxy-3,6-Dimethoxy-α,17-Dimethyl-6,14-Ethenomorphinan-7-Methanol
CAS No.	13965-70-3
Molecular Formula	C27H37NO4
Molecular Weight	439.59 g/mol
Synonyms	Buprenorphine Impurity F; 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3,6-dimethoxy-α,17-dimethyl-α-(1,1-dimethylethyl)-, (2S,5R,7R)-; (2S,5R,7R)-4,5-Epoxy-3,6-dimethoxy-α,17-dimethyl-α-(1,1-dimethylethyl)-6,14-ethenomorphinan-7-methanol; Buprenorphine Related Compound F; tert-Butylbuprenorphine; UNII-7J3S2P3H1N
EINECS	Contact for details

Quality Control

Our (αs,5α,7α)-α-(1,1-Dimethylethyl)-4,5-Epoxy-3,6-Dimethoxy-α,17-Dimethyl-6,14-Ethenomorphinan-7-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets exacting specifications for research and development use. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.