Description

Malonic Acid, [1,3-14C] is a carbon-14 labeled isotopologue of malonic acid, a fundamental dicarboxylic acid. This radiolabeled compound is essential for precise metabolic pathway tracing and pharmacokinetic studies, offering researchers a critical tool for investigating biochemical mechanisms. It is primarily utilized by scientists and manufacturers in the pharmaceutical, agrochemical, and life science research sectors for advanced analytical applications.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the citric acid cycle (Krebs cycle) and other biochemical pathways in vivo and in vitro.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of new drug candidates.
• Biochemical Research: Serves as a labeled precursor in the enzymatic synthesis of other labeled compounds and for studying enzyme mechanisms.
• Agrochemical Research: Employed in metabolism studies of herbicides, pesticides, and plant growth regulators.
• Environmental Fate Studies: Used to trace the degradation pathways and environmental persistence of organic compounds.
• Standards for Analytical Chemistry: Acts as an internal standard or reference material in advanced analytical techniques like LC-MS and radio-HPLC.

Basic Information

Product Name	Malonic Acid, [1,3-14C]
CAS No.	13878-08-5
Molecular Formula	C14CH4O4 / C3H4O4 (¹⁴C labeled)
Molecular Weight	106.05 g/mol (for unlabeled); Specific activity provided on COA
Synonyms	Propanedioic-1,3-14C Acid; Dicarboxymethane-1,3-14C; 1,3-14C-Malonic Acid; Carbon-14 Labeled Malonic Acid; Methanedicarboxylic-1,3-14C Acid; [1,3-14C]Malonate; Radiolabeled Malonic Acid
EINECS	Contact for details

Quality Control

Every batch of Malonic Acid, [1,3-14C] is produced and analyzed under strict quality systems to ensure high chemical and radiochemical purity, meeting the exacting requirements of research and development. Certificates of Analysis (COA) are provided, detailing parameters such as specific activity, radiochemical purity (by radio-HPLC or TLC), and chemical purity. Our quality commitment supports compliance with GLP (Good Laboratory Practice) standards.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability and specific activity. Follow all applicable radiation safety and laboratory guidelines for handling and storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Specific Activity	As per customer requirement (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent (if supplied in solution)	Specified on label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.