Description

Bis(4-Trifluoromethylphenyl)Chlorophosphine is a specialized organophosphorus compound featuring two electron-withdrawing trifluoromethylphenyl groups, which significantly influence its reactivity and stability. This compound is a high-value intermediate prized for its role in synthesizing advanced ligands and catalysts used in cross-coupling reactions and other transition metal-catalyzed processes. It is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise building blocks for creating novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for compounds requiring phosphine-based ligands.
• Catalyst & Ligand Synthesis: Serves as a critical building block for manufacturing specialized phosphine ligands used in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi).
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Material Science: Employed in the creation of advanced polymers and functional materials with specific electronic or surface properties.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the chlorophosphine moiety into complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	Bis(4-Trifluoromethylphenyl)Chlorophosphine
CAS No.	13685-24-0
Molecular Formula	C14H8ClF6P
Molecular Weight	356.63 g/mol
Synonyms	Chlorobis[4-(trifluoromethyl)phenyl]phosphine; Bis(p-trifluoromethylphenyl)chlorophosphine; Chlorobis(4-trifluoromethylphenyl)phosphine; (4-Trifluoromethylphenyl)2PCl; Phosphinous chloride, bis[4-(trifluoromethyl)phenyl]-; Bis(4-(trifluoromethyl)phenyl)chlorophosphane
EINECS	Contact for details

Quality Control

Our production of Bis(4-Trifluoromethylphenyl)Chlorophosphine adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized using advanced analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry, and well-ventilated area. Due to its moisture-sensitive and easily oxidized nature, the container should be opened and handled only in a controlled, dry environment. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
31P NMR	Conforms
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.