Description

Trilostane CAS NO 13647-35-3 is a synthetic steroid analog that functions as a competitive inhibitor of the enzyme 3β-hydroxysteroid dehydrogenase. This compound is of significant commercial and research interest due to its specific action in modulating steroid hormone biosynthesis. It is primarily required by the pharmaceutical industry for therapeutic development and by research institutions for biochemical studies.

Application

• Pharmaceutical Active Ingredient: Key component in the formulation of medications for treating Cushing's syndrome and certain hormone-dependent conditions.
• Veterinary Medicine: Used in the treatment of hyperadrenocorticism (Cushing's disease) in dogs.
• Endocrinology Research: A vital tool for studying adrenal steroidogenesis and the regulation of cortisol production in laboratory settings.
• Biochemical Standard: Serves as a high-purity reference standard for analytical method development and quality control in pharmaceutical testing.
• Mechanistic Studies: Employed in preclinical research to investigate pathways related to steroid metabolism and enzyme inhibition.

Basic Information

Item	Detail
Product Name	Trilostane
CAS No.	13647-35-3
Molecular Formula	C20H27NO3
Molecular Weight	329.44 g/mol
Synonyms	Modrenal; 4α,5-Epoxy-17β-hydroxy-3-oxoandrostane-2α-carbonitrile; WIN 24,540; 2α-Cyano-4α,5-epoxy-17β-hydroxy-3-oxo-5α-androstane; Trilostanum; Trilostan; 5α-Androst-2-eno[3,2-c]pyrazol-17-ol
EINECS	Contact for details

Quality Control

Our Trilostane is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, to ensure it meets high-grade specifications suitable for pharmaceutical and research use. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container in a well-ventilated area and away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.