Description

4-Methyl-2,3,5,6-Tetrafluorothiophenol is a specialized organofluorine building block featuring a thiol functional group on a perfluorinated aromatic ring. This compound is valued for its unique reactivity, serving as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries for introducing fluorinated thiophenol moieties.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated ligands and charge-transport materials in electronic displays.
• Polymer Modification: Employed to introduce fluorinated aromatic thiol groups into polymers, improving their chemical resistance and surface properties.
• Ligand for Catalysis: Can be used to prepare fluorinated thiolate ligands for metal complexes in homogeneous catalysis.
• Surface Functionalization: Applied in self-assembled monolayers (SAMs) on gold or other surfaces for sensor development.

Basic Information

Product Name	4-Methyl-2,3,5,6-Tetrafluorothiophenol
CAS No.	13634-89-4
Molecular Formula	C7H4F4S
Molecular Weight	196.17 g/mol
Synonyms	2,3,5,6-Tetrafluoro-4-methylbenzenethiol; 4-Methyltetrafluorothiophenol; Perfluoro-4-methylthiophenol; α,α,α,α-Tetrafluoro-4-methylthiophenol; 2,3,5,6-Tetrafluoro-p-toluenethiol; 4-(Methyl)tetrafluorobenzenethiol; p-Methyltetrafluorothiophenol
EINECS	Contact for details

Quality Control

Our 4-Methyl-2,3,5,6-Tetrafluorothiophenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at 2-8°C (refrigerated) or as specified on the label. Due to its light-sensitive nature and high volatility, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent oxidation and degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.