Description

Succinic Acid, [1,4-14C] is a high-purity, carbon-14 labeled isotopologue of succinic acid, a key intermediate in the Krebs cycle. This radiolabeled compound is essential for advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer to elucidate biochemical pathways. It is a critical tool for scientists in pharmaceutical R&D, agrochemical development, and biochemistry who require definitive data on compound fate, absorption, and degradation.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer in in vitro and in vivo studies to map the citric acid cycle and related metabolic fluxes.
• Drug Metabolism and Pharmacokinetics (DMPK): Critical for ADME (Absorption, Distribution, Metabolism, Excretion) studies to track the fate of new chemical entities and their metabolites.
• Biochemical Research: Employed in enzymatic assays and studies of mitochondrial function and energy metabolism.
• Environmental Fate Studies: Applied in agrochemical research to study the degradation pathways and environmental impact of compounds.
• Biomaterial and Polymer Research: Serves as a labeled precursor in the development and degradation studies of bio-based polymers like polybutylene succinate (PBS).

Basic Information

Product Name	Succinic Acid, [1,4-14C]
CAS No.	13613-74-6
Molecular Formula	C4H614C2O4
Molecular Weight	~120.1 g/mol (exact mass depends on specific activity)
Synonyms	Butanedioic-1,4-14C Acid; Amber Acid-1,4-14C; 1,4-14C-Succinic Acid; [1,4-14C]Succinic Acid; Ethylenesuccinic-1,4-14C Acid; 14C-Succinic Acid; Radiolabeled Succinic Acid
EINECS	Contact for details

Quality Control

Every batch of Succinic Acid, [1,4-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing, including radiochemical purity analysis by HPLC, to ensure compliance with the stringent requirements of research and regulatory applications. Certificates of Analysis (COA) detailing specific activity, radiochemical purity, and analytical methods are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. Handle and store in accordance with all applicable radiation safety regulations and guidelines. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Specific Activity	Customizable (mCi/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent (for solutions)	As specified (e.g., Water, Ethanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.