Description

trans-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is a chiral amino alcohol derivative with a fused indane ring system, serving as a versatile and high-value synthetic building block. Its primary commercial value lies in its role as a key chiral intermediate for the synthesis of complex pharmaceutical active ingredients and fine chemicals. This compound is particularly relevant for research and production in the pharmaceutical industry, where it is used in developing central nervous system (CNS) agents, enzyme inhibitors, and other bioactive molecules. The hydrochloride salt form enhances stability and handling for industrial-scale processes.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in neurological and psychiatric therapeutic areas.
• Asymmetric Catalyst Ligand Precursor: Used to develop chiral ligands for metal-catalyzed asymmetric reactions, enabling the production of enantiomerically pure compounds.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural product analogs and specialty agrochemicals.
• Academic & Contract Research: Serves as a starting material for medicinal chemistry research and process development in academic and R&D laboratories.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	trans-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride
CAS No.	13575-73-0
Molecular Formula	C9H12ClNO
Molecular Weight	185.65 g/mol
Synonyms	(1R,2S)-rel-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride; (1S,2R)-rel-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride; trans-2-Aminoindan-1-ol hydrochloride; (±)-trans-2-Amino-1-indanol hydrochloride; rac-trans-2-Amino-1-indanol hydrochloride; 2-Aminoindan-1-ol HCl; 1H-Inden-1-ol, 2-amino-2,3-dihydro-, hydrochloride, (1R-trans)-
EINECS	Contact for details

Quality Control

Our trans-2-Amino-2,3-dihydro-1H-inden-1-ol hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (trans-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.