Description

N-(Trimethylsilyl)Acetamide (CAS NO 13435-12-6) is a versatile organosilicon reagent primarily used as a powerful silylating agent. It is critical for introducing the trimethylsilyl (TMS) protecting group onto reactive functional groups like hydroxyls and amines, thereby enabling complex synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity intermediates for sensitive chemical transformations.

Application

• Pharmaceutical Synthesis: As a key silylating agent for protecting sensitive functional groups (e.g., -OH, -NH) during the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Peptide Chemistry: Used in the preparation and modification of amino acids and peptides, facilitating reactions by protecting amine functionalities.
• Agrochemical Manufacturing: Employed in the synthesis of advanced pesticides and herbicides where selective protection and deprotection steps are required.
• Silicon-Based Polymer Production: Serves as a monomer or modifying agent in the synthesis of specialized silicones and silicon-containing polymers.
• Analytical Chemistry: Utilized as a derivatization agent in Gas Chromatography (GC) and Mass Spectrometry (MS) to improve the volatility and detectability of polar compounds.
• Organic Semiconductor Research: Acts as a precursor or surface modifying agent in the development of organic electronic materials.

Basic Information

Product Name	N-(Trimethylsilyl)Acetamide
CAS No.	13435-12-6
Molecular Formula	C5H13NOSi
Molecular Weight	131.25 g/mol
Synonyms	N-(Trimethylsilyl)acetamide; Acetamide, N-(trimethylsilyl)-; TMS-Acetamide; N-(TMS)Acetamide; N-Trimethylsilylacetamide; N,O-Bis(trimethylsilyl)acetamide related; N-Acetyltrimethylsilylamine; 1-(Trimethylsilyl)ethan-1-imine
EINECS	236-563-3

Quality Control

Our N-(Trimethylsilyl)Acetamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to meet the rigorous standards required by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and strong bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.