Description

Propargyltrimethylsilane is a versatile organosilicon building block featuring a reactive terminal alkyne group protected by a trimethylsilyl moiety. This compound is valued for its dual functionality, enabling efficient carbon-carbon bond formation and serving as a key precursor in complex organic synthesis. It is primarily sought by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing molecular scaffolds and functional polymers.

Application

• Pharmaceutical Intermediates: A key synthon in the preparation of active pharmaceutical ingredients (APIs), particularly for Sonogashira and other cross-coupling reactions.
• Agrochemical Synthesis: Used in the development of novel fungicides, herbicides, and plant growth regulators.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty silicones, conductive polymers, and advanced resins.
• Organic Synthesis Reagent: Employed in palladium-catalyzed coupling reactions and as a protected propargyl anion equivalent for nucleophilic additions.
• Liquid Crystal & OLED Materials: Acts as a building block for creating organic semiconductors and light-emitting materials.
• Surface Modification: Used to introduce alkyne functionalities onto surfaces for subsequent "click chemistry" bioconjugation.

Basic Information

Product Name	Propargyltrimethylsilane
CAS No.	13361-64-3
Molecular Formula	C6H12Si
Molecular Weight	112.25 g/mol
Synonyms	Trimethyl(2-propyn-1-yl)silane; (Trimethylsilyl)methylacetylene; 3-(Trimethylsilyl)-1-propyne; 1-Trimethylsilyl-2-propyne; Propargyltrimethylsilane; TMS-Propargyl; Propargyl TMS; Trimethylsilylpropyne
EINECS	236-423-1

Quality Control

Our Propargyltrimethylsilane is manufactured under strict quality management systems. Each batch is analyzed to ensure high chemical purity and consistency, with specifications typically meeting or exceeding industry standards for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flames. Containers should be kept tightly sealed when not in use to prevent evaporation and potential moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	0.74 - 0.78 g/mL
Refractive Index (n20D)	1.410 - 1.420

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.