Description

3-Hydroxy-5-Phenyl-1,3-Dihydro-Benzo[E][1,4]Diazepin-2-One is a high-purity benzodiazepine derivative, a key advanced pharmaceutical intermediate (API) in the synthesis of complex therapeutic agents. Its value lies in its precise molecular structure, which serves as a critical building block for developing active pharmaceutical ingredients (APIs) with targeted pharmacological effects. This compound is essential for research institutions and pharmaceutical manufacturers focused on central nervous system (CNS) drug discovery, process development, and scale-up production.

Application

• Pharmaceutical Intermediate: Primary use as a core scaffold in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Research & Development: Serves as a critical reference standard and starting material in medicinal chemistry for CNS drug discovery programs.
• Process Chemistry: Used in the development and optimization of synthetic routes for complex heterocyclic compounds in pilot and commercial-scale manufacturing.
• Analytical Standard: Employed as a high-purity standard for method development, validation, and quality control (HPLC, GC, NMR) in analytical laboratories.

Basic Information

Product Name	3-Hydroxy-5-Phenyl-1,3-Dihydro-Benzo[E][1,4]Diazepin-2-One
CAS No.	13127-21-4
Molecular Formula	C₁₇H₁₄N₂O₂
Molecular Weight	278.31 g/mol
Synonyms	3-Hydroxy-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one; 5-Phenyl-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 3-Hydroxy-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one; NSC 113929; 5-Phenyl-3-hydroxy-1,4-benzodiazepin-2-one; Benzo[e][1,4]diazepin-2-one, 1,3-dihydro-3-hydroxy-5-phenyl-
EINECS	Contact for details

Quality Control

Our 3-Hydroxy-5-Phenyl-1,3-Dihydro-Benzo[E][1,4]Diazepin-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.