Description

L-Methionine-Methyl-D3 is a stable isotope-labeled analog of the essential amino acid L-Methionine, where three hydrogen atoms on the methyl group are replaced by deuterium (D). This compound is a critical tool in advanced research and development, enabling precise metabolic and pharmacokinetic studies through mass spectrometry and NMR techniques. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications requiring high isotopic purity and chemical stability.

Application

• Internal Standard in Mass Spectrometry: Serves as a quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of endogenous methionine levels in biological samples.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate methionine metabolism, protein synthesis rates, and transmethylation pathways in vivo and in vitro.
• Pharmaceutical R&D: Employed in the development and validation of bioanalytical methods for new drug candidates, ensuring precise pharmacokinetic and bioavailability data.
• Stable Isotope-Labeled Biomarker: Acts as a tracer in clinical research to study conditions related to sulfur amino acid metabolism, such as liver function and homocysteine regulation.
• NMR Spectroscopy: Provides a non-radioactive, stable label for structural elucidation and dynamic studies of proteins and peptides.
• Quality Control Reference: Used as a certified reference material (CRM) in analytical laboratories to ensure the accuracy and reliability of testing methods.

Basic Information

Item	Detail
Product Name	L-Methionine-Methyl-D3
CAS No.	13010-53-2
Molecular Formula	C5H8D3NO2S
Molecular Weight	152.23 g/mol
Synonyms	(2S)-2-Amino-4-(methyl-d3)sulfanylbutanoic acid; L-Methionine-methyl-d3; (S)-2-Amino-4-((trideuteriomethyl)sulfanyl)butanoic acid; Methionine (methyl-d3); Deuterated L-Methionine; L-Met-methyl-d3; Stable Isotope Labeled Methionine; Methionine-d3
EINECS	Contact for details

Quality Control

Our L-Methionine-Methyl-D3 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (typically ≥98 atom % D), chemical purity (by HPLC), and specific optical rotation. We adhere to relevant standards for high-purity reference materials, and custom specifications for GMP or research-grade material are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the product under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Optical Rotation	[α]20/D: +21.0° to +24.0° (c=1 in 1N HCl)
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.