Description

Ammonium-D4 Deuteroxide is a deuterated form of ammonium hydroxide, where hydrogen atoms are replaced with deuterium. This isotopic labeling is critical for applications requiring minimal interference from proton signals, such as in advanced NMR spectroscopy and reaction mechanism studies. It serves as a fundamental reagent in the synthesis of deuterated compounds for pharmaceutical research, materials science, and analytical chemistry. The product is supplied with a high level of isotopic purity to ensure consistent and reliable performance in sensitive applications.

Application

• As a deuterium source and strong base in the synthesis of deuterium-labeled active pharmaceutical ingredients (APIs) and intermediates.
• Critical reagent in Nuclear Magnetic Resonance (NMR) spectroscopy for solvent suppression and as a chemical shift reference.
• Used in mechanistic studies and kinetic isotope effect (KIE) experiments in academic and industrial research laboratories.
• Precursor for preparing other deuterated reagents and catalysts used in organic synthesis and materials science.
• Employed in the electronics industry for cleaning and etching processes in the manufacture of semiconductors.
• Utilized in analytical chemistry as a mobile phase modifier in Liquid Chromatography-Mass Spectrometry (LC-MS) to improve detection.

Basic Information

Product Name	Ammonium-D4 Deuteroxide
CAS No.	12168-30-8
Molecular Formula	D4NO (or ND4OD)
Molecular Weight	41.08 g/mol
Synonyms	Deuterated Ammonium Hydroxide; Ammonium Deuteroxide-d4; Deuterium Oxide Solution of Ammonia-d4; Ammonia-d4 in D2O; ND4OD; Tetradeuteroammonium Hydroxide; Heavy Ammonia Hydroxide; Ammonium-d4 Hydroxide
EINECS	Contact for details

Quality Control

Our Ammonium-D4 Deuteroxide is manufactured under strict quality control protocols to ensure high isotopic and chemical purity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D atom %), assay, and impurity profiles. We adhere to relevant industry standards and can provide material suitable for research and development purposes. Certificates of Analysis are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat and incompatible materials such as strong acids and metals. Due to its highly volatile nature, ensure containers are securely sealed and stored upright. Recommended storage temperature is between 2°C and 8°C to minimize decomposition and volatilization.

Specification

Item	Specification
Appearance	Colorless clear solution
Identification (IR)	Conforms
Deuterium Isotopic Enrichment	≥ 99.5 atom % D
Assay (as ND4OD)	20 - 30 wt.% in D2O (or as specified)
pH	> 13 (20% solution)
Conductivity	Contact for details
Total Impurities (NMR)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.