Description

2-(3-Chloropropanoyl)-1,2,3,4-Tetrahydroisoquinoline is a versatile and high-purity organic building block of significant interest in advanced chemical synthesis. This compound serves as a critical intermediate for the development of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel heterocyclic frameworks and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those containing the tetrahydroisoquinoline scaffold, which is prevalent in compounds with neurological and cardiovascular activity.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactive chloropropanoyl side chain for further functionalization.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for constructing complex heterocycles and for studying novel ring-forming reactions and amide coupling methodologies.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Potential use in the synthesis of organic semiconductors, photoactive materials, and advanced polymers.

Basic Information

Product Name	2-(3-Chloropropanoyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	10579-67-6
Molecular Formula	C12H14ClNO
Molecular Weight	223.70 g/mol
Synonyms	1,2,3,4-Tetrahydro-2-(3-chloropropionyl)isoquinoline; 3-Chloro-1-(1,2,3,4-tetrahydro-2-isoquinolyl)-1-propanone; 2-(3-Chloropropionyl)-1,2,3,4-tetrahydroisoquinoline; N-(3-Chloropropanoyl)-1,2,3,4-tetrahydroisoquinoline; 10579-67-6; 3-Chloro-1-(3,4-dihydro-1H-isoquinolin-2-yl)propan-1-one
EINECS	Contact for details

Quality Control

Our 2-(3-Chloropropanoyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.