Description

2,4-Bis-Trimethylsilanyloxy-Pyrimidine CAS NO 10457-14-4 is a high-purity, silylated pyrimidine derivative used as a key synthetic intermediate and protecting group reagent. This compound is critical for enabling complex organic synthesis, particularly in the development of nucleoside analogs and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for precision chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Protecting Group Reagent: Used to protect hydroxyl groups on pyrimidine rings during multi-step synthetic sequences.
• Agrochemical Synthesis: Intermediate in the production of certain herbicides and fungicides.
• Material Science Research: Precursor for creating functionalized organic molecules and ligands for catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of specialized fine chemicals.
• Academic & Industrial R&D: Used in laboratory-scale research for developing new synthetic methodologies.

Basic Information

Product Name	2,4-Bis-Trimethylsilanyloxy-Pyrimidine
CAS No.	10457-14-4
Molecular Formula	C10H20N2O2Si2
Molecular Weight	256.45 g/mol
Synonyms	2,4-Bis(trimethylsiloxy)pyrimidine; Pyrimidine, 2,4-bis[(trimethylsilyl)oxy]-; 2,4-Bis-O-(trimethylsilyl)pyrimidine; 2,4-Di-O-trimethylsilylpyrimidine; 2,4-Bis(trimethylsilyloxy)pyrimidine; 2,4-Pyrimidinediol, bis(trimethylsilyl) ether; TMS-protected 2,4-dihydroxypyrimidine
EINECS	Contact for details

Quality Control

Our 2,4-Bis-Trimethylsilanyloxy-Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available for all shipments. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.