Description

(2S)-1-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid is a high-purity, chiral bicyclic amino acid derivative, serving as a critical building block in advanced organic synthesis. Its unique, rigid quinuclidine-based structure makes it an invaluable scaffold for constructing complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for developing novel active pharmaceutical ingredients (APIs) and chiral ligands.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of sophisticated drug candidates, including potential neuroactive compounds and enzyme inhibitors.
• Asymmetric Catalyst Ligand: Utilized as a core structure for developing novel chiral ligands in transition metal catalysis for enantioselective reactions.
• Agrochemical Research: Employed in the design and synthesis of new chiral pesticides and herbicides with improved efficacy and selectivity.
• Chemical Biology Probe: Serves as a constrained amino acid analog for studying protein structure-function relationships and enzyme mechanisms.
• Material Science: Investigated as a monomer or additive for creating polymers with specific chiral or rigid-rod properties.
• Academic & R&D: A fundamental reagent for methodological development in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	(2S)-1-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid
CAS No.	10344-62-4
Molecular Formula	C8H13NO2
Molecular Weight	155.19 g/mol
Synonyms	(S)-Quinuclidine-2-carboxylic acid; (2S)-2-Quinuclidinecarboxylic acid; L-Quinuclidine-2-carboxylic acid; (S)-1-Azabicyclo[2.2.2]octane-2-carboxylic acid; (S)-2-Carboxyquinuclidine; (S)-Quinuclidinic acid; (2S)-1-Azabicyclo[2.2.2]octan-2-carboxylic acid
EINECS	233-751-8

Quality Control

Our (2S)-1-Azabicyclo[2.2.2]Octane-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.