Description

D-Lysine-4,4,5,5-D4 2Hcl is a high-purity, isotopically labeled derivative of the essential amino acid L-lysine, specifically deuterated at the 4,4,5,5 positions. This compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reproducibility in analytical measurements. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and nutritional science sectors for advanced metabolic studies, proteomics, and pharmacokinetic research.

Application

• Quantitative Mass Spectrometry (MS) & LC-MS/MS: Serves as a stable isotope-labeled internal standard for the precise quantification of endogenous L-lysine and related metabolites in complex biological matrices.
• Pharmacokinetic & Metabolic Tracing Studies: Enables accurate tracking of drug metabolism, nutrient absorption, and amino acid flux in preclinical and clinical research.
• Proteomics & Biomarker Discovery: Used in stable isotope labeling by amino acids in cell culture (SILAC) and other techniques for relative and absolute protein quantification.
• Clinical Diagnostics & Newborn Screening: Essential for developing and validating highly accurate diagnostic assays for inborn errors of metabolism, such as hyperlysinemia.
• Nutritional Science Research: Facilitates studies on protein metabolism, amino acid requirements, and the bioavailability of lysine in fortified foods and supplements.
• Pharmaceutical Quality Control (QC): Employed in the analysis of lysine-containing active pharmaceutical ingredients (APIs) and finished drug products to ensure potency and purity.

Basic Information

Product Name	D-Lysine-4,4,5,5-D4 2Hcl
CAS No.	10303-72-7
Molecular Formula	C6H10D4N2O2 • 2HCl
Molecular Weight	231.16 g/mol
Synonyms	(2R)-2,6-Diamino-4,4,5,5-tetradeuteriohexanoic acid dihydrochloride; D-Lysine-d4 dihydrochloride; (R)-2,6-Diaminocaproic-4,4,5,5-d4 acid dihydrochloride; Deuterated D-Lysine 2HCl; D-Lysine (4,4,5,5-D4) hydrochloride; Lysine-d4 (D-isomer) dihydrochloride; (R)-2,6-Diaminohexanoic-4,4,5,5-d4 acid dihydrochloride
EINECS	Contact for details

Quality Control

Every batch of D-Lysine-4,4,5,5-D4 2Hcl is manufactured and tested under strict quality management systems to ensure the highest standards of isotopic purity and chemical integrity required for sensitive analytical applications. We provide comprehensive Certificates of Analysis (COA) that detail isotopic enrichment (D%), chemical purity, and confirm identity and absence of critical impurities. Our quality commitment aligns with the rigorous demands of research and regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.