Description

(-)-5,9,10,14B-Tetrahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepin-6(7H)-One is a high-purity, chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the creation of novel therapeutic agents targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of specialized active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used as a high-purity analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize pharmacological profiles for new drug candidates.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Academic Research: Utilized in university and institutional labs for studying benzodiazepine chemistry, pharmacology, and developing new synthetic methodologies.

Basic Information

Product Name	(-)-5,9,10,14B-Tetrahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepin-6(7H)-One
CAS No.	10243-45-5
Molecular Formula	C₁₉H₁₇ClN₂O
Molecular Weight	324.80 g/mol
Synonyms	(-)-2-Chloro-5-methyl-5,9,10,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one; (5R,14bS)-2-Chloro-5-methyl-5,9,10,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6(7H)-one; 10243-45-5; UNII-8J2N1K3K3V; SCHEMBL218062; CHEMBL3183453; DTXSID40423923; BDBM50388857
EINECS	Contact for details

Quality Control

Our (-)-5,9,10,14B-Tetrahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepin-6(7H)-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.