Description

(+)-2-Chloro-5,9,10,14B-Tetrahydro-5-Methylisoquino[2,1-D][1,4]Benzodiazepin-6(7H)-One is a high-purity chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical pharmacological reference standard and a versatile chemical building block for synthesizing novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuroscience, medicinal chemistry, and the development of central nervous system (CNS) targeted drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Pharmacological Research: Used as a reference compound in in-vitro and in-vivo studies to investigate receptor binding affinity, metabolic pathways, and structure-activity relationships (SAR).
• Medicinal Chemistry: Serves as a core scaffold for designing and optimizing new chemical entities (NCEs) with potential anxiolytic, sedative, or muscle relaxant properties.
• Analytical Standard: Employed as a certified reference material (CRM) for method development, validation, and quality control (QC) in analytical laboratories (HPLC, GC-MS, NMR).
• Process Chemistry Development: Used in route scouting and optimization for the scalable, GMP-compliant manufacturing of complex drug candidates.

Basic Information

Product Name	(+)-2-Chloro-5,9,10,14B-Tetrahydro-5-Methylisoquino[2,1-D][1,4]Benzodiazepin-6(7H)-One
CAS No.	10171-69-4
Molecular Formula	C₁₉H₁₇ClN₂O
Molecular Weight	324.80 g/mol
Synonyms	(+)-2-Chloro-5-methyl-5,6,7,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6-one; (6R)-2-Chloro-5-methyl-5,6,7,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6-one; (R)-2-Chloro-5-methyl-5,6,7,14b-tetrahydroisoquino[2,1-d][1,4]benzodiazepin-6-one; L-838417; L838417; Chiral Benzodiazepine Derivative; Isoquinobenzodiazepine
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality management systems. Every batch is characterized using advanced analytical techniques including HPLC, GC-MS, NMR, and chiral analysis to ensure identity, purity, and enantiomeric excess. Comprehensive Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.