Description

7-Chloro-5-(trifluoromethyl)[1,3]thiazolo[5,4-d]pyrimidine is a high-value heterocyclic building block featuring a fused thiazolopyrimidine core substituted with chloro and trifluoromethyl groups. This compound matters for its role as a critical synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiazolopyrimidine scaffold.
• Chemical Biology Probe: Serves as a core structure for designing molecular probes to study biological pathways and enzyme functions.
• Material Science Research: Investigated as a building block for advanced organic electronic materials due to its electron-deficient aromatic system.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and library production.

Basic Information

Product Name	7-Chloro-5-(trifluoromethyl)[1,3]thiazolo[5,4-d]pyrimidine
CAS No.	1998-59-0
Molecular Formula	C7H2ClF3N3S
Molecular Weight	255.62 g/mol
Synonyms	7-Chloro-5-(trifluoromethyl)thiazolo[5,4-d]pyrimidine; 7-Chloro-5-trifluoromethyl[1,3]thiazolo[5,4-d]pyrimidine; Thiazolo[5,4-d]pyrimidine, 7-chloro-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-7-chlorothiazolo[5,4-d]pyrimidine; 7-Chloro-5-(trifluoromethyl)-[1,3]thiazolo[5,4-d]pyrimidine; 1998-59-0; AKOS005258213; CTK8G8115
EINECS	Contact for details

Quality Control

Our 7-Chloro-5-(trifluoromethyl)[1,3]thiazolo[5,4-d]pyrimidine is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP-like controls for non-GMP use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.